Compare UK GLP-1 Weight Loss Clinics

GLP-1 (glucagon-like peptide-1) receptor agonists are prescription medicines that mimic the GLP-1 gut hormone to reduce appetite and slow gastric emptying. In the UK, the main approved options for weight management are semaglutide (Wegovy), tirzepatide (Mounjaro — a dual GIP/GLP-1 agonist), and liraglutide (Saxenda). Clinical trials show 10–22% average body weight loss over 68 weeks. All are given by weekly or daily subcutaneous injection.

Yes. All GLP-1 receptor agonists are prescription-only medicines (POMs) in the UK. A registered doctor or nurse prescriber must assess your eligibility — typically a BMI of 30 or above, or 27 or above with a weight-related condition such as type 2 diabetes or hypertension. Legitimate clinics require a medical consultation and may request GP records or blood tests. Be wary of any provider offering GLP-1 medication without a proper clinical assessment.

The most common side effects are gastrointestinal: nausea (affects up to 44% of patients), vomiting, diarrhoea, and constipation. These typically improve after the first 4–8 weeks as the body adjusts to dose escalation. Rare but serious side effects include pancreatitis and gallbladder problems. All GLP-1 medicines are contraindicated in personal or family history of medullary thyroid carcinoma or MEN2 syndrome. Always discuss your full medical history with your prescribing clinician.

Wegovy (semaglutide 2.4mg weekly) received NICE approval in March 2023 for use in specialist NHS weight management services. However, NHS availability remains very limited due to supply constraints and specialist service capacity. Most patients currently access GLP-1 medications through private online clinics. Note: Ozempic (semaglutide 1mg) is licensed only for type 2 diabetes on the NHS and should not be prescribed off-label for weight loss alone.

We score on seven independently verified factors: Average Cost (20%) — monthly prescription cost mapped to a 2.5–7.5 scale; Clinical Support (15%) — quality of clinical oversight rated 1–5 stars; Subscription Discount (10%) — whether a discounted ongoing plan is available; Support Options (10%) — number of contact channels available (email, chat, WhatsApp, phone); Mobile App (10%) — companion app quality rated 1–5 stars; Customer Score (10%) — verified patient ratings, initially marked Pending; and Delivery Cost (5%) — free delivery scores 10, paid delivery is scored by charge. Only CQC or GPhC-registered providers are included.